Randomized phase 2 NCT03678883 report of elraglusib plus gemcitabine/nab-paclitaxel in first-line metastatic pancreatic ductal adenocarcinoma.
Chemotherapy
Chemotherapy is a conventional oncology treatment or care pathway used within standard cancer care, usually under the direction of oncology specialists and with disease-specific indications. In cancer care, it should be evaluated by evidence level, intended use, safety, interactions, and whether it is being used as conventional treatment, supportive care, an experimental adjunct, or an alternative claim.
Open-access systematic review of preclinical fasting-mimicking diet studies in cancer models. It summarizes evidence that FMD can alter tumor metabolism and may enhance chemotherapy, hormone therapy, targeted therapy, immunotherapy, or vitamin C effects in animal studies, while emphasizing that the evidence base is primarily preclinical.
Systematic review/meta-analysis of acupuncture for nausea/vomiting induced by highly emetogenic chemotherapy; reported potential benefit but insufficient certainty due to limitations.
Medical encyclopedia entry noting hyperthermia is usually combined with radiation or chemotherapy and is studied across multiple cancers.
Short 2026 Medical Gas Research article proposing hydrogen inhalation as a potential approach for radiotherapy/chemotherapy-induced hearing loss in cancer patients.
NCI overview of how chemotherapy is used to treat cancer, including curative, adjuvant, neoadjuvant, palliative, route, cycle, and side-effect concepts.
NCI overview of local, regional, and whole-body hyperthermia, cancers studied, adjunctive use with radiation/chemotherapy, availability, and side effects.
Clinical and translational report from the BREAKFAST phase 2 trial of cyclic fasting-mimicking diet with anthracycline-taxane chemotherapy in early triple-negative breast cancer. The article reports safety/compliance signals, strong pathologic response outcomes in the enrolled cohort, and early downmodulation of tumor glycolysis as a possible predictor of response.
Randomized trial of FMD during neoadjuvant chemotherapy in HER2-negative breast cancer; reported less grade III vomiting and neutropenia in the FMD group and favorable hematologic differences.
Mayo Clinic patient education page covering diagnostic tests, staging, surgery, chemotherapy, radiation, immunotherapy, clinical trials, and palliative care for pancreatic cancer.
ClinicalTrials.gov record for DIRECT-2, a fasting-mimicking diet program with chemotherapy in HR-positive HER2-negative breast cancer.
Explains chemotherapy as systemic anticancer drug treatment, how treatment choice depends on cancer type, and common combination-regimen concepts.
Systematic review of nine publications/eight studies with 379 patients; concluded data are low/moderate quality, heterogeneous, underpowered, and insufficient to prove benefit, with caution about weight loss.
Proponent case report by an oncology/radiotherapy specialist describing ENS/SCENAR/COSMODIC treatment alongside prior hormone therapy and chemotherapy in inoperable prostate cancer, with PSA and symptom claims.
Review of intermittent/periodic fasting during chemotherapy, summarizing small human trials and future directions.
Pilot randomized sham-controlled trial of acupuncture for chemotherapy-induced peripheral neuropathy in breast cancer patients.
Randomized phase 2 DIRECT trial of FMD during neoadjuvant chemotherapy for HER2-negative stage II/III breast cancer; reported adherence challenges and selected response/DNA-damage signals.
Randomized trial of behavioral interventions for anticipatory nausea and vomiting during chemotherapy; included as behavioral symptom-management context adjacent to biofeedback and relaxation training.
Review covering hydrogen gas in cancer treatment, including chemotherapy/radiotherapy adverse effects, inflammation, ROS, apoptosis, tumor growth, and preclinical/early clinical evidence.
Review of molecular background, current knowledge, and clinical trials evaluating short-term fasting in cancer treatment.
Randomized assessor-blinded wait-list-controlled trial of acupuncture for chemotherapy-induced peripheral neuropathy in cancer patients.
Systematic review/meta-analysis of acupuncture for chemotherapy-induced peripheral neuropathy.
High-level review of fasting/FMD mechanisms in cancer, including differential stress resistance, differential stress sensitization, metabolite/growth-factor shifts, and clinical application cautions.
Outcomes study relevant to patients choosing complementary approaches while refusing conventional treatment. Added as safety/evidence context for natural-only and no-chemo protocol research.
Randomized cross-over pilot trial of 60-hour fasting in breast and ovarian cancer chemotherapy; reported feasibility and quality-of-life/fatigue signals without serious adverse effects.
Public-facing news article on preclinical research suggesting curcumin may help address chemotherapy resistance in pancreatic cancer.
MD Anderson randomized pilot trial: neurofeedback group improved CIPN symptoms versus waitlist control, with EEG changes predictive of symptom reduction.
Dose-escalation pilot study of 24, 48, and 72 hour fasting around platinum-based chemotherapy; found feasibility and mostly mild fasting-related symptoms.
NaturalNews article making broad claims about turmeric and cancer cells. Flagged for collection because of natural-treatment relevance; claims should be compared against peer-reviewed evidence.
Randomized pilot study of short-term fasting during (neo)adjuvant chemotherapy in HER2-negative breast cancer.
Preclinical study relevant to chemotherapy-associated oxaliplatin neuronal damage rather than direct cancer control.
Short research highlight about vitamin D receptor activation in pancreatic stellate cells and preclinical combination work with chemotherapy.
Research news summary about a vitamin D derivative making pancreatic tumors more vulnerable to chemotherapy in preclinical work by targeting fibrosis/wound-repair mechanisms.
Translational and early clinical ovarian cancer study combining high-dose parenteral ascorbate with carboplatin/paclitaxel; reported reduced chemotherapy-associated toxicity and mechanistic rationale.
Early case series of 10 cancer patients voluntarily fasting around chemotherapy; reported reduced self-described side effects in some patients, but uncontrolled design.
FTC action against marketers of herbal products and a Zapper electrical unit for unsubstantiated claims involving cancer, AIDS, Alzheimer disease, diabetes, and claims that surgery/chemotherapy were unnecessary.
Small randomized trial of Traumeel S mouthwash for chemotherapy-induced stomatitis in children undergoing stem cell transplantation; cited in Cochrane review.
Mayo randomized double-blind oral vitamin C trial in advanced cancer patients with no prior chemotherapy; found no therapeutic benefit versus placebo.
NCI patient summary covering diagnosis, treatment phases, chemotherapy, targeted therapy, immunotherapy, stem cell transplant, and follow-up for acute lymphoblastic leukemia.
NCI patient summary for adult acute myeloid leukemia, including standard chemotherapy, targeted therapy options, supportive care, and recurrent disease treatment.
NCI patient summary about adrenocortical carcinoma diagnosis, staging, surgery, radiation therapy, chemotherapy, targeted therapy, immunotherapy, and clinical trials.
NCI patient summary describing AIDS-related lymphoma, staging, chemotherapy, radiation therapy, stem cell transplant, targeted therapy, and treatment alongside HIV care.
NCI rare tumor page describing angiosarcoma, where it occurs, diagnosis, and aggressive treatment with surgery, radiation therapy, and chemotherapy.
Patient-facing explanation of chemotherapy goals, routes, treatment planning, and what receiving chemotherapy can be like.
Clinical overview of why chemotherapy is used and major treatment settings, including primary, adjuvant, neoadjuvant, and symptom-control use.
NCI patient summary for childhood CNS atypical teratoid/rhabdoid tumor, including surgery, chemotherapy, radiation therapy, stem cell transplant, and recurrent disease.
NCI-listed pilot phase II trial record for fasting-mimicking diet with chemo-immunotherapy in metastatic non-small cell lung cancer. The listing describes the hypothesis that FMD may enhance cancer-cell vulnerability and reduce treatment side effects.
NCI guide to searching cancer clinical trials by disease, subtype, stage, side effects, trial type, location, and drug or treatment.
Open-access review of pancreatic acinar cell carcinoma covering epidemiology, imaging, pathology, molecular features, surgery, chemotherapy, and prognosis.
Disease-aware source pass harvested this article while searching for Esophageal Cancer. Review title, author, date, and summary before relying on this record.
NCI listing for administratively complete pilot trial of short-term fasting around platinum chemotherapy in advanced solid tumors.
Open-access review of current management of alveolar soft part sarcoma, including surgery, radiotherapy, chemotherapy controversy, targeted agents, and checkpoint inhibitors.
NCI treatment-type overview placing chemotherapy among surgery, radiation, immunotherapy, targeted therapy, hormone therapy, hyperthermia, and stem cell transplant.