Oncology-specific evidence summary: routes include rectal insufflation, ozonated water, and autohaemotherapy; clinical cancer evidence is limited, no survival benefit shown, and inhalation/direct IV use raise safety concerns.
Ozone Therapy
Medical ozone therapy uses a controlled oxygen-ozone mixture through routes such as major autohemotherapy, ozonated water/oils, rectal insufflation, ozonated saline, and local/topical applications. In cancer it is promoted mainly as an adjunctive/supportive therapy, but clinical evidence remains limited and it is not an approved cancer treatment.
Literature review focused on ozone therapy in breast cancer, including in vitro, in vivo, and human reports.
Evidence review of preclinical and limited clinical literature exploring ozone as a potential local/systemic anticancer approach.
Review proposing ozone as a possible adjuvant during radiotherapy/chemotherapy based on preclinical work, tumor oxygenation hypotheses, and limited clinical experience; concludes randomized trials are needed.
Full-text version of the Clavo review on ozone as an adjuvant cancer therapy.
Evidence classification review for systemic ozone applications, especially major autohemotherapy and rectal insufflation.
Animal study of ozonated water and anti-tumor effects.
Discusses oxygen-ozone therapy with emphasis on ozonated saline infusion and rectal insufflation.
Working hypothesis paper on tumor hypoxia/normoxia and ozone therapy in cancer.
Regulatory source stating FDA position on ozone as a toxic gas and setting device limits/warnings.
Chemical hazard sheet identifying ozone exposure routes and respiratory/eye target organs.
EPA public-health page on respiratory effects from breathing ozone pollution.